Volume 4, Issue 1, June 2018, Page: 5-10
Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids
Farid Hidayat, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Dian Pratiwi, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Titus Kurnia, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Taslim, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Ahmad Syukri, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Paskalis Indra, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Muzakkir Amir, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Peter Kabo, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Robert Setiadji, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Received: Feb. 23, 2018;       Accepted: Mar. 20, 2018;       Published: Apr. 12, 2018
DOI: 10.11648/j.ijhpebs.20180401.12      View  989      Downloads  69
Abstract
Background: People with Acquired Immunodeficiency Syndrome (AIDS) are at risk of developing structural and functional cardiac abnormalities that are unrelated to common cardiac risk factors (e.g. Hypertension, Diabetes Mellitus, Smoking habit). AIDS may be associated with chronic inflammation related to multiple factors related to the Human Immunodeficiency Virus (HIV) infection and its complications. Cardiac abnormality with AIDS may be subclinical and may present long before the onset of clinical heart failure symptoms. Objectives: To anticipate the risk of cardiovascular morbidity in people with AIDS. Methods: The researchers studied 52 people with AIDS in this observational cross-sectional study, which were further categorized into those with cluster of differentiation 4 (CD4) count of less than 200/mm3 and those with CD4 count of more than 200/mm3. Echocardiographic examinations were done to evaluate cardiac structural and functional values. Results: Mean age was 33 years old, predominantly male (71.2%). The group with a CD4 count of less than 200/mm3 showed higher Left Ventricular Mass Index (LVMI) values (113.08 vs. 39.99, p=0.012), a higher risk of developing diastolic dysfunction (OR 9.35, CI 95%, p=0.018) and pericardial effusion (OR 3.83, CI 95%, p=0.048). Conclusion: A CD4 count of less than 200/mm3 is associated with a higher risk of developing cardiac diastolic dysfunction and structural abnormalities.
Keywords
HIV, AIDS, Echocardiography, Diastolic Dysfunction
To cite this article
Farid Hidayat, Dian Pratiwi, Titus Kurnia, Taslim, Ahmad Syukri, Paskalis Indra, Muzakkir Amir, Peter Kabo, Robert Setiadji, Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids, International Journal of HIV/AIDS Prevention, Education and Behavioural Science. Vol. 4, No. 1, 2018, pp. 5-10. doi: 10.11648/j.ijhpebs.20180401.12
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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