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Dysregulation of Phospholipid Metabolism in Synaptic Membranes and Their Role in Encephalopathy Forming After a Hemorrhagic Shock

Received: 31 May 2015     Accepted: 14 June 2015     Published: 1 July 2015
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Abstract

Phospholipids (PLs) of neuronal membranes are active universal neuromodulators. They regulate many functions of the neurons, including receptors signaling, which during a hemorrhagic shock (HS) get damaged, leading to encephalopathy. An analysis of the data, presented in this review, suggests that the dysregulation of PL metabolism in synaptic membranes is a key mechanism of encephalopathy during HS. Stabilizing the PL composition of the neuronal membranes may become one of the most important treatment methods for shock-induced disorders of brain functions.

Published in American Journal of BioScience (Volume 3, Issue 4)
DOI 10.11648/j.ajbio.20150304.13
Page(s) 133-140
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Phospholipids, Synaptic Membranes, Hemorrhagic Shock

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    Galina Fedorovna Leskova. (2015). Dysregulation of Phospholipid Metabolism in Synaptic Membranes and Their Role in Encephalopathy Forming After a Hemorrhagic Shock. American Journal of BioScience, 3(4), 133-140. https://doi.org/10.11648/j.ajbio.20150304.13

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    Galina Fedorovna Leskova. Dysregulation of Phospholipid Metabolism in Synaptic Membranes and Their Role in Encephalopathy Forming After a Hemorrhagic Shock. Am. J. BioScience 2015, 3(4), 133-140. doi: 10.11648/j.ajbio.20150304.13

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    AMA Style

    Galina Fedorovna Leskova. Dysregulation of Phospholipid Metabolism in Synaptic Membranes and Their Role in Encephalopathy Forming After a Hemorrhagic Shock. Am J BioScience. 2015;3(4):133-140. doi: 10.11648/j.ajbio.20150304.13

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  • @article{10.11648/j.ajbio.20150304.13,
      author = {Galina Fedorovna Leskova},
      title = {Dysregulation of Phospholipid Metabolism in Synaptic Membranes and Their Role in Encephalopathy Forming After a Hemorrhagic Shock},
      journal = {American Journal of BioScience},
      volume = {3},
      number = {4},
      pages = {133-140},
      doi = {10.11648/j.ajbio.20150304.13},
      url = {https://doi.org/10.11648/j.ajbio.20150304.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20150304.13},
      abstract = {Phospholipids (PLs) of neuronal membranes are active universal neuromodulators. They regulate many functions of the neurons, including receptors signaling, which during a hemorrhagic shock (HS) get damaged, leading to encephalopathy. An analysis of the data, presented in this review, suggests that the dysregulation of PL metabolism in synaptic membranes is a key mechanism of encephalopathy during HS. Stabilizing the PL composition of the neuronal membranes may become one of the most important treatment methods for shock-induced disorders of brain functions.},
     year = {2015}
    }
    

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    T1  - Dysregulation of Phospholipid Metabolism in Synaptic Membranes and Their Role in Encephalopathy Forming After a Hemorrhagic Shock
    AU  - Galina Fedorovna Leskova
    Y1  - 2015/07/01
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajbio.20150304.13
    DO  - 10.11648/j.ajbio.20150304.13
    T2  - American Journal of BioScience
    JF  - American Journal of BioScience
    JO  - American Journal of BioScience
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    SN  - 2330-0167
    UR  - https://doi.org/10.11648/j.ajbio.20150304.13
    AB  - Phospholipids (PLs) of neuronal membranes are active universal neuromodulators. They regulate many functions of the neurons, including receptors signaling, which during a hemorrhagic shock (HS) get damaged, leading to encephalopathy. An analysis of the data, presented in this review, suggests that the dysregulation of PL metabolism in synaptic membranes is a key mechanism of encephalopathy during HS. Stabilizing the PL composition of the neuronal membranes may become one of the most important treatment methods for shock-induced disorders of brain functions.
    VL  - 3
    IS  - 4
    ER  - 

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Author Information
  • Laboratory of nanopathology, nanotoxicology and biomedical nanotechnologies, Institute of General Pathology und Pathophysiology, Moscow, Russia

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