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Decentralized Care for People Living with HIV in Koumpentoum (Senegal): Prevalence and Factors Associated with Unfavourables Outcomes from 2005 to 2022

Received: 11 November 2022    Accepted: 28 November 2022    Published: 27 December 2022
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Abstract

Background: In a context of challenges to achieve the three (95), we studied the decentralized management of HIV infections in the health district of Koumpentoum. Our research focused on the prevalence and factors associated with unfavorable outcomes from (2005) to (2022). Methodology: This was a retrospective, descriptive and analytical study. The dependent variable was unfavorable outcomes, which included deaths and dropouts. The independent variables were related to socio-demographic, clinical, para-clinical, therapeutic and outcome characteristics. In the multi variate analysis, multiple logistic regression was used. Results: A total of (782) patients were included. There was a clear female predominance with (66.5%). More than half (56.26%) of the patients were under (45) years of age. Two thirds of them were living in a couple (65.98%). Almost three quarters (73.15%) had no income-generating activity. At inclusion, co-infection with tuberculosis was (2.56%). Viral load was not performed in more than three quarters (76.6%). Of those who had a viral load test (42.07%), the level was undetectable. Almost all (95.03%) were put on first line antiretroviral and less than half of them (43.86%) were on Dolutegravir. In terms of outcomes, (36.83%) of the patients were lost to follow-up, (20.08%) died and (43.09%) were still on follow-up. Factors statistically and significantly associated with an unfavorable outcomes were age less than (45) years (ORa = 2.15 [1.16-3.97]; p=0.014), not living with a partner (OR = 3.35 [2.7-4.7]; p<0. 001), not having an income-generating activity (OR = 2.08 [1.51-2.87]; p=0.008), presenting tuberculosis at inclusion (OR = 5.78 [1.32-25.21]; p<0.008) and no treatment with Dolutegravir (ORa = 23.74 [11.97-47.1]; p<0.001). Conclusion: Improving the management of HIV patients in Koumpentoum health district will require an active search for those who have been lost to follow-up, awareness raising and financial protection for young people and vulnerable groups, systematic screening for tuberculosis and widespread use of Dolutegravir.

Published in International Journal of HIV/AIDS Prevention, Education and Behavioural Science (Volume 8, Issue 2)
DOI 10.11648/j.ijhpebs.20220802.14
Page(s) 69-75
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Care, Decentralized, PLHIV, Unfavourables, Outcomes, Koumpentoum, Senegal

References
[1] HIV infection and AIDS in e Pilly Trop Infectious and Tropical Diseases (2022). College of scholars of infectious and tropical diseases (CMIT), 3rd web edition: 610-64. Available from: www.infectiologie.com
[2] Sleasman JW, Goodenow MM. Pathogenesis and natural history of HIV infection (1991). J Fla Med Assoc [Internet]. [cited 2022 Nov 5]; 78 (10): 678–81. Available from: https://pubmed.ncbi.nlm.nih.gov/1753233/
[3] Shampo MA, Kyle RA. Robert C. Gallo discoverer of the AIDS virus (2001). Mayo Clin Proc. 76 (10): 968. doi: 10.4065/76.10.968. PMID: 11605696.
[4] United Nations Aids Organization (UNAIDS) (2022). Fact sheet: latest statistics on the state of the AIDS pandemic. 6p. Available from: https://www.unaids.org/fr/resources/fact-sheet
[5] United Nations aigainst Aquired Immuno Deficiency Syndrom (UNAIDS) (2021). Country factsheets: Senegal. Available from: https://www.unaids.org/fr/regionscoun tries/countries/senegal
[6] Republic of Senegal. National AIDS Control Council (2022). Rapport annuel (2021). 64p.
[7] Report of the medical technical committee meeting of October 1 (2022). Koumpentoum Health District. 6p.
[8] National Agency of Demography and Statistics (2021) Economic and Social Situation of Senegal in 2019. Ministry of Economy, Planning and Cooperation, Republic of Senegal. 310 p. Available from: https://www.ansd.sn/ressources/ses/SES_2019.pdf
[9] National Agency of Demography and Statistics (2021). Economic and Social Situation of Tambacounda region in 2019. Ministry of Economy, Planning and Cooperation, Republic of Senegal. 97 p. Available from: https://www.ansd.sn/ressources/ses/SES-Tambacounda-2019.pdf
[10] Sakomota, Y., Ishiguro, M. and Kitagawa, G. (1968).Aikake Information Criterion Statistics. D. Reidel, Dordrecht.
[11] Lemoshow, S., Hosmer, J. and May, S. (2008). Applied Survival Analysis: Regression Modeling of Time-to-Event Data. Wiley Series in Probabilities and Statistics, Wiley, Hoboken. https://doi.org/10.1002/9780470258019
[12] Gueye NFN, Ka D, Tall AB, Ndiaye K, Ndiaye AA, Cisse VMP, and al. (2017). Prevalence of Hypertension and Associated Factors in Patients Living with HIV Followed at the Ambulatory Treatment Center (CTA) of Fann National University Hospital in Dakar. Health (Irvine Calif). 09 (04): 727–37.
[13] Bongenya, B. I., Bulanda, B. I., Bukongo, R. N., Chuga, D., Botomuito, H. T., Kabasele, J.-Y. D. and Kamangu, E. N. (2022) Prevalence of Opportunist Infections among the Professionals Sex Workers and Their Customers Living with the VIH under ARV in Kinshasa. Open Access Library Journal, 9, 1-7. doi: 10.4236/oalib.1107927.
[14] Kwobah CM, Mwangi AW, Koech JK, Simiyu GN, Siika AM. (2012). Factors Associated with First-Line Antiretroviral Therapy Failure amongst HIV-Infected African Patients : A Case-Control Study. World J AIDS. (2): 271–8.
[15] Sani K, Kadri Sani, Salifou Ibrahim Alkassoum, Harouna Amadou Mahaman Laouali, Djibo Sayo Adamou, Garba Abdoul Azize, Boureima Karimou, Daou Mamane, First Line Antiretroviral Therapy (ART) in Regional Hospital of Niamey (Niger): Socio-demographic Characteristics and Treatment Outcome, American Journal of Nursing and Health Sciences. 3 (3): 62-66. doi: 10.11648/j.ajnhs.20220303.13
[16] Patricia Fener, Claire Criton. Risk factors for HIV/AIDS infection in women (2007). [Research report] INIST-V - 07-02, Institute of Scientific and Technical Information (INIST-CNRS). 62 p.
[17] Diop, E. H. C. A. (2019). Prevalence and factors associated with unfavourables outcomes (death and loss to follow-up) among HIV PLWHA followed at the Tambacounda regional hospital from January 2009 to December 2014. Dissertation DES of Infectious and Tropical Diseases. Cheikh Anta Diop University, Dakar, 81 p.
[18] Ndiaye AA, Tall AB, Ba A, Diop D, Ngom NF, Sow PG and al. (2022). Case-Control Study on the Vulnerability of Women to HIV, Kaolack, 2019. Open J Epidemiol. 12 (03): 355–66.
[19] Temah CT. The determinants of the HIV/AIDS epidemic in sub-Saharan Africa (2009). Journal of Economy and Development. 23 (1-2): 73-106.
[20] Konaté, I., Goïta, D., Dembélé, J., Coulibaly, B., Cissoko, Y., Soumaré, M., Fofana, A., Koné, O., Sogoba, D., Oumar, A., & Dao, S. (2018). Risk Factors of HIV Contamination in Serodiscordant Couples Followed in the Service of Infectious and Tropical Diseases of the CHU du Point-G. Health Sciences And Disease, 19 (4). Aivalable from: https://www.hsd-fmsb.org/index.php/hsd/article/view/1172
[21] Ba S, Ba ND, Sembene L, Anne TSB, Dia H, Ndiaye JL and al. (2020). Factors Associated with Adverse Therapeutic Outcomes in People Living with HIV (PLHIV) Monitored in Roi Baudouin Health Care Center, Dakar, Senegal. World J AIDS. 10 (01): 23–35.
[22] Bbosa N, Kaleebu P, Ssemwanga D. HIV subtype diversity worldwide (2019). Curr Opin HIV AIDS. 14 (3): 153–60.
[23] Jaffar S, Grant AD, Whitworth J, Smith PG, Whittle H. The natural history of HIV-1 and HIV-2 infections in adults in Africa: a literature review. Bull World Health Organ. 2004 Jun; 82 (6): 462-9. Erratum in: Bull World Health Organ. 2004 Aug; 82 (8): 571. PMID: 15356940; PMCID: PMC2622848.
[24] Mirambo MM, Kidenya BR, Silago V, Mkumbo E, Mujuni A, Mmanga KJ and al. (2019). Hepatitis B and Hepatitis C among Human Immunodeficiency Virus Infected Patients at a District Hospital in Mwanza, Tanzania. World J AIDS. 09 (01): 1–10.
[25] Rogers K, Gertrude N, Enoch M. (2019). Pulmonary Tuberculosis in HIV/AIDS Patients Attending Art Clinic in Bududa General Hospital, Bududa District, Uganda. J Tuberc Res. 07 (03): 135–42.
[26] Hassan A, Olukolade R, Ogbuji Q, Onyemocho A, Okwuonye L, Igbabul S. and al (2016). Evaluation of Tuberculosis Treatment Outcome of TB/HIV Co-Infection: A Four-Year Retrospective Cohort Study in HIV-Prevalent Setting of North Central Nigeria. J Tuberc Res. 04 (03): 122–33.
[27] Gezae KE, Abebe HT, Gebretsadik LG (2019). Incidence and predictors of LTFU among adults with TB/HIV co-infection in two governmental hospitals, Mekelle, Ethiopia, 2009-2016: Survival model approach. BMC Infect Dis. 19 (1): 1–9.
[28] WHO (2021). Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. Geneva: World Health Organization. 594 p.
[29] WHO (2019). WHO recommends Dolutegravir as the preferred HIV treatment option in all populations. Available from: https://www.who.int/fr/news/item/22-07-2019-who-recommends-dolutegravir-as-preferred-hiv-treatment-option-in-all-populations
[30] Toure A, Cisse D, Kadio K, Camara A, Traore FA, Delamou A, Sidibe S, Kouyate C, Bangoura IS, Diallo MM, Tounkara TM, Traoré F, Sow MS, Khanafer N, Cissé M. (2019). Factors associated with dropouts of patients on antiretroviral therapy in an outpatient HIV treatment center in Conakry, Guinea. Journal of Epidemiology and Public Health. 25: S0398-7620(18)30694-1. doi: 10.1016/j.respe.2018.04.057. Pub Med Google Scholar.
[31] Bognounou R, Kabore M, Diendéré A, Diallo I, Sagna Y, Guira O et al (2015). Characteristics of "lost to follow-up" patients and determinants of loss to follow-up in HIV-infected patients in Ouagadougou, Burkina Faso. Bull la Soc Pathol Exot. 108 (3): 197-200..
[32] Brinkhof MW, Pujades-Rodriguez M, Egger M (2009). Mortality of patients lost to follow-up in antiretroviral treatment programs in resource-limited settings: systematic review and meta-analysis. PLoS One. 4 (6): e5790. Doi: 10.1371/journal.pone.0005790. PMID: 19495419; PMCID: PMC2686174.
[33] Izudi J, Tamwesigire IK, Bajunirwe F. (2020). Treatment success and mortality among adults with tuberculosis in rural eastern Uganda: a retrospective cohort study. BMC Public Health. 20 (1): 501. doi: 10.1186/s12889-020-08646-0. PMID: 32295549; PMCID: PMC7161267.
[34] Keugoung B, Fouelifack FY, Fotsing R, Macq J, Meli J, Criel B. (2014). A systematic review of missed opportunities for improving tuberculosis and HIV/AIDS control in Sub-Saharan Africa: what is still missed by health experts? Pan Afr Med J. 18: 320. doi: 10.11604/pamj.2014.18.320.4066. PMID: 25478041; PMCID: PMC4250026.
Cite This Article
  • APA Style

    Diop El Hadji Cheikh Abdoulaye, Bop Martial Coly, Ndiaye Abdoul Aziz, Sarr Mama Waly, Sambou Moussa Missette, et al. (2022). Decentralized Care for People Living with HIV in Koumpentoum (Senegal): Prevalence and Factors Associated with Unfavourables Outcomes from 2005 to 2022. International Journal of HIV/AIDS Prevention, Education and Behavioural Science, 8(2), 69-75. https://doi.org/10.11648/j.ijhpebs.20220802.14

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    ACS Style

    Diop El Hadji Cheikh Abdoulaye; Bop Martial Coly; Ndiaye Abdoul Aziz; Sarr Mama Waly; Sambou Moussa Missette, et al. Decentralized Care for People Living with HIV in Koumpentoum (Senegal): Prevalence and Factors Associated with Unfavourables Outcomes from 2005 to 2022. Int. J. HIV/AIDS Prev. Educ. Behav. Sci. 2022, 8(2), 69-75. doi: 10.11648/j.ijhpebs.20220802.14

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    AMA Style

    Diop El Hadji Cheikh Abdoulaye, Bop Martial Coly, Ndiaye Abdoul Aziz, Sarr Mama Waly, Sambou Moussa Missette, et al. Decentralized Care for People Living with HIV in Koumpentoum (Senegal): Prevalence and Factors Associated with Unfavourables Outcomes from 2005 to 2022. Int J HIV/AIDS Prev Educ Behav Sci. 2022;8(2):69-75. doi: 10.11648/j.ijhpebs.20220802.14

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  • @article{10.11648/j.ijhpebs.20220802.14,
      author = {Diop El Hadji Cheikh Abdoulaye and Bop Martial Coly and Ndiaye Abdoul Aziz and Sarr Mama Waly and Sambou Moussa Missette and Barry Abdou and Dog AdelaideNdew},
      title = {Decentralized Care for People Living with HIV in Koumpentoum (Senegal): Prevalence and Factors Associated with Unfavourables Outcomes from 2005 to 2022},
      journal = {International Journal of HIV/AIDS Prevention, Education and Behavioural Science},
      volume = {8},
      number = {2},
      pages = {69-75},
      doi = {10.11648/j.ijhpebs.20220802.14},
      url = {https://doi.org/10.11648/j.ijhpebs.20220802.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhpebs.20220802.14},
      abstract = {Background: In a context of challenges to achieve the three (95), we studied the decentralized management of HIV infections in the health district of Koumpentoum. Our research focused on the prevalence and factors associated with unfavorable outcomes from (2005) to (2022). Methodology: This was a retrospective, descriptive and analytical study. The dependent variable was unfavorable outcomes, which included deaths and dropouts. The independent variables were related to socio-demographic, clinical, para-clinical, therapeutic and outcome characteristics. In the multi variate analysis, multiple logistic regression was used. Results: A total of (782) patients were included. There was a clear female predominance with (66.5%). More than half (56.26%) of the patients were under (45) years of age. Two thirds of them were living in a couple (65.98%). Almost three quarters (73.15%) had no income-generating activity. At inclusion, co-infection with tuberculosis was (2.56%). Viral load was not performed in more than three quarters (76.6%). Of those who had a viral load test (42.07%), the level was undetectable. Almost all (95.03%) were put on first line antiretroviral and less than half of them (43.86%) were on Dolutegravir. In terms of outcomes, (36.83%) of the patients were lost to follow-up, (20.08%) died and (43.09%) were still on follow-up. Factors statistically and significantly associated with an unfavorable outcomes were age less than (45) years (ORa = 2.15 [1.16-3.97]; p=0.014), not living with a partner (OR = 3.35 [2.7-4.7]; pConclusion: Improving the management of HIV patients in Koumpentoum health district will require an active search for those who have been lost to follow-up, awareness raising and financial protection for young people and vulnerable groups, systematic screening for tuberculosis and widespread use of Dolutegravir.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Decentralized Care for People Living with HIV in Koumpentoum (Senegal): Prevalence and Factors Associated with Unfavourables Outcomes from 2005 to 2022
    AU  - Diop El Hadji Cheikh Abdoulaye
    AU  - Bop Martial Coly
    AU  - Ndiaye Abdoul Aziz
    AU  - Sarr Mama Waly
    AU  - Sambou Moussa Missette
    AU  - Barry Abdou
    AU  - Dog AdelaideNdew
    Y1  - 2022/12/27
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ijhpebs.20220802.14
    DO  - 10.11648/j.ijhpebs.20220802.14
    T2  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    JF  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    JO  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    SP  - 69
    EP  - 75
    PB  - Science Publishing Group
    SN  - 2575-5765
    UR  - https://doi.org/10.11648/j.ijhpebs.20220802.14
    AB  - Background: In a context of challenges to achieve the three (95), we studied the decentralized management of HIV infections in the health district of Koumpentoum. Our research focused on the prevalence and factors associated with unfavorable outcomes from (2005) to (2022). Methodology: This was a retrospective, descriptive and analytical study. The dependent variable was unfavorable outcomes, which included deaths and dropouts. The independent variables were related to socio-demographic, clinical, para-clinical, therapeutic and outcome characteristics. In the multi variate analysis, multiple logistic regression was used. Results: A total of (782) patients were included. There was a clear female predominance with (66.5%). More than half (56.26%) of the patients were under (45) years of age. Two thirds of them were living in a couple (65.98%). Almost three quarters (73.15%) had no income-generating activity. At inclusion, co-infection with tuberculosis was (2.56%). Viral load was not performed in more than three quarters (76.6%). Of those who had a viral load test (42.07%), the level was undetectable. Almost all (95.03%) were put on first line antiretroviral and less than half of them (43.86%) were on Dolutegravir. In terms of outcomes, (36.83%) of the patients were lost to follow-up, (20.08%) died and (43.09%) were still on follow-up. Factors statistically and significantly associated with an unfavorable outcomes were age less than (45) years (ORa = 2.15 [1.16-3.97]; p=0.014), not living with a partner (OR = 3.35 [2.7-4.7]; pConclusion: Improving the management of HIV patients in Koumpentoum health district will require an active search for those who have been lost to follow-up, awareness raising and financial protection for young people and vulnerable groups, systematic screening for tuberculosis and widespread use of Dolutegravir.
    VL  - 8
    IS  - 2
    ER  - 

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Author Information
  • Koumpentoum Health District, Ministry of Health and Social Protection, Koumpentoum, Senegal

  • Training and Research Unit in Health and Sustainable Development, Alioune DIOP University, Bambey, Senegal

  • Training and Research Unit in Health and Sustainable Development, Alioune DIOP University, Bambey, Senegal

  • Koumpentoum Health District, Ministry of Health and Social Protection, Koumpentoum, Senegal

  • Koumpentoum Health District, Ministry of Health and Social Protection, Koumpentoum, Senegal

  • Koumpentoum Health District, Ministry of Health and Social Protection, Koumpentoum, Senegal

  • Koumpentoum Health District, Ministry of Health and Social Protection, Koumpentoum, Senegal

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